nejm-abstractUse to write the NEJM structured abstract — four headed sections (Background, Methods, Results, Conclusions), ≤250 words, with the trial registration number and funding source, leading the Results with the primary outcome reported as an effect size with a 95% CI. Late-stage polish skill.
nejm-citationUse to convert references to NEJM's Vancouver / ICMJE numbered style — numbered in order of appearance, limited author lists then et al., NLM journal abbreviations, and a capped reference count. Late-stage style pass.
nejm-ethicsUse to confirm clinical ethics and research-integrity requirements for an NEJM submission — IRB/ethics-committee approval and informed consent per the Declaration of Helsinki, ICMJE conflict-of-interest disclosures and authorship criteria, the role-of-the-funding-source statement, and the ICMJE data
nejm-figures-tablesUse to build NEJM clinical display items correctly — Table 1 baseline characteristics by group (with standardized differences, not P values), Kaplan-Meier curves with numbers-at-risk, forest plots for subgroups and meta-analyses, and the CONSORT participant flow diagram.
nejm-fitUse this first, before any writing, to stress-test whether a clinical study clears NEJM's bar — practice-changing clinical impact, methodological rigor, and generalizability. Decides NEJM vs Lancet/JAMA vs a specialty journal.
nejm-rebuttalUse after NEJM reviews arrive — often including a dedicated statistical reviewer and an editor letter — to triage the decision, answer statistical comments rigorously, and draft a point-by-point response that quotes each comment, the response, and the revised manuscript text. Do not run before the m
nejm-reportingUse to select and enforce the correct EQUATOR reporting guideline for a clinical study headed to NEJM — CONSORT for RCTs (with the participant flow diagram), STROBE for observational, PRISMA for systematic reviews — and to build the required checklist and diagram before submission.
nejm-statisticsUse to enforce NEJM's clinical statistical reporting — confidence intervals over bare P values, the pre-specified intention-to-treat primary analysis, multiplicity control for secondary endpoints, pre-specified subgroups with interaction tests, missing-data handling, and absolute risk with NNT along
nejm-study-designUse to confirm study-design rigor and the mandatory prospective trial registration, protocol, and statistical analysis plan before writing up a clinical study for NEJM. Surfaces registration problems early — they cannot be fixed retroactively.
nejm-submissionUse as the final preflight before submitting to NEJM — a complete clinical checklist across significance, registration, reporting guidelines, abstract, statistics, display items, ethics, references, and required files. Bundles a checklist and a clinical cover-letter template.
nejm-workflowUse when deciding which nejm-* sub-skill to invoke next, or when sequencing a clinical manuscript from significance test through response to reviewers for The New England Journal of Medicine. Routes — it does not replace — the specialized skills.
nejm-writingUse to structure and tighten an NEJM Original Article into terse IMRAD — short main text (~2700 words), limited references, claim-first results, and a sober discussion with explicit limitations and calibrated clinical implications. Enforces NEJM's plain, concise house style.