tahoe-public

Read-only access to Tahoe's single-cell perturbation data through the Tahoe public tools, for drug-discovery research. Look up covered drugs, doses, cell lines and genes; read drug annotations (targets, mechanism of action, approval status); and retrieve expression, drug-versus-vehicle differential expression, perturbation markers, pathway scores and embedding distance from vehicle. Read the validated signature readout for a cancer process: one per process, where one exists, in one dataset only. Compare a compound's response with annotated mechanism classes; compare drug responses between genotype- or lineage-defined groups of cell lines; correlate a cell line's baseline expression or driver-gene status with its drug response (exploratory); and rank drug-induced relative depletion and cell-cycle effects per cell line across three doses. Includes guarded read-only SQL and analysis guidance. Requires a Tahoe account; available datasets and capabilities depend on the account.

1 skill · 1 MCP server